Work Packages

For the execution of METHYLOMIC, the overall project is organised into seven Work Packages (WPs). WP1-5 form the scientific, clinical, and technological core; the remaining WPs (WP6-7) are essential integrating parts of the work plan to secure the project’s results, timelines, and short- and long-term impacts.

WP1: Bioinformatics and algorithm development

The main aim of this WP is to generate, improve and refine the algorithms capable of predicting response to biological treatment based on epigenetic DNA methylation markers that we found to discriminate responders from non-responders to treatment with 3 different mainstream biologicals in CD. Further, we also test the validity of this approach in Rheumatoid Arthritis (RA) and Psoriasis (PsO).

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WP2: Rapid NGS targeted methylation assay development

The overall aim of this WP is to develop a targeted methylation assay that will be useful in clinical use, that could work as a Companion Diagnostic. Such an assay will be used in a clinical trial in CD patients in WP3 that will put our idea to the test in clinical practice by the treating physicians by using an app device.

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WP6: Dissemination, Exploitation and Communication

The overall aim of WP6 is to maximise the scientific, economic, and societal impacts of METHYLOMIC by implementing appropriate strategies for dissemination, exploitation and communication, and setting-up stakeholder workshops and cutting-edge trainings.

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WP7: Management and Coordination

The overall aim of WP7 is to ensure that the project’s objectives are realised and that the project is implemented in compliance with the EC Grant Agreement and CA.

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